Two days in Brussels

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Tuesday, March 31 and Wednesday, February 1 I went to Brussels by train. It is sad to see the permanent heavy military presence around Brussels main train station.

Microsoft had invited me to participate in the ‘Health Digital Transformation’ at the Microsoft Executive Briefing Center, because my company is a founding member of the ‘AI in Health Partner Alliance’ (along with Microsoft and 20 other tech companies) which was launched at the event. The event was attended by executives from tech companies, researchers, journalist, and policy makers.

I was also in Brussels to meet some people from the European Parliament to discuss official business.

“Fun” fact: did you know that 1/4 of the whole EU Parliament budget goes to translation services?

This Revolution needs a Revolution

Yesterday I went with my wife and son to visit the Victoria & Albert’s Museum exhibition You Say You Want a Revolution? Records and Rebels 1966-1970. The aim of the exhibition was quite clear:

How have the finished and unfinished revolutions of the late 1960s changed the way we live today and think about the future?

I was very much looking forward to visiting the exhibition. It is SO timely, and SO needed, I thought.

After visiting it, I left enraged. Why? After all, it was very well “put together”, full of artifacts and information, with a fancy sound system, and beautifully arranged and orchestrated.

ORGANIZED

More importantly, it was not a nostalgic attempt at regurgitating old revolutionary slogans.

What enraged me is how co-opted the whole collection felt. How all those efforts and sacrifices, how all that energy and suffering from past revolutionaries, has been assimilated by the system.

From the ® Registered slogans to the “no photographs” signs at the entrance (to which I, OF COURSE, paid no attention to whatsoever):

® slogan!

To the texts denouncing powerful corporations and states controlling Western media making it difficult to broadcast alternative opinions. You don’t say??!! How about adding “even museums”?

You don't say??!!

Of course, the whole thing had a watered down flavor, “ready for the masses to consume it” (at over£17 or over $20 per ticket). Not just because of the large dedicated-store (“Exit through the gift store” as Banksy brilliantly highlighted), where many appealing objects were for sale for nostalgics and revolutionary wannabes.

Interesting mash up poster

But also for the paternalistic tone of the whole exhibition, surgically isolating issues (identity, sexuality, peace, music, fashion…), even (correctly) including the new contemporary totemic theological substitute: technology.

Origins of Personal Computers

I was very happy and proud to tell my son that his grandmother was in Paris throwing cobblestones to the police in the student revolts of 1969; that his grandfather took me, when I was a little kid, to see a forbidden theater play during Spain’s democratic transition, fearing the secret police repression; that I participated as a kid in discussions with adults about anarchism and communism, when both were outlawed in Spain; and that I have participated in some of the revolutions and protests that came in the decades after that.

I’m not angry because they took “my” revolutions and repackaged them for easy digestion by accommodating masses. That was foreseeable, and an obvious result of the reigning empire of consumerist capitalism.

I’m not even nostalgically refusing to accept that times have changed.

What really annoyed me and made me angry was the lack of reference to a combative present, to the continuation of the struggle.

The fact that they showed, at the end of the exhibition “How have the finished and unfinished revolutions of the late 1960s changed the way we live today” but completely left out “and think about the future” is what enraged me. Particularly as Trump is president in the USA, May PM in GB, the PP rule Spain, the far right advances in France…

We need to remember that the fight is not over, that fascism is not only back, but stronger and more powerful than ever. We, all of us, and the institutions that serve us, including museums, have a duty to promote thoughtful debate around ethics and values, and fiercely protest and fight through self-organisation, unity, and collaboration. We owe it to ourselves, we owe it to those who fought for us in the past, we owe it to those who will come after us.

If the urban bourgeoisie wants to be the first to fall under the boot of the oppressors again, so be it. If proto and pseudo-intellectuals endlessly self-delude themselves into thinking that our democracies and institutions will save us from authoritarian demagogues, fascist megalomaniacs, and our own blind pursuit of endless consumerism, so be it. In the meantime, I will be teaching my children about the struggle and participating in the smartest and most effective way I can.

My EU policy recommendation published: “Hacking Policy. Exploring Innovative Ways to Advance Policy Reform”

Under the title “Hacking Policy. Exploring Innovative Ways to Advance Policy ReformStartupEurope has published a report listing the Policy Recommendations that came out of the Policy Hackathon in San Francisco, where my team won the competition.

Download it here.

Invited to the UK-China Hi! Technology event in London

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For reasons beyond the scope of this post I was invited to participate in the UK-China Hi! Technology event in London.

The event was well attended by a large number of entrepreneurs, funds and investors from the UK and China.

The highlight of the event, for me, other than a couple of really interesting contacts, was to see all these suited-up people lining up to try the VR sets (HTC, Oculus, Hololens, etc). The clear winner was Robot Recall for the Oculus platform.

Spare time fun: protein structure analysis of mutations causing inheritable diseases

Most people I know would not consider protein structure analysis of mutations causing inheritable diseases “spare time fun”. Then again, most people I know don’t think I am like most people they know.

This week I’m a “single-dad”, since my wife is traveling. So my spare time right now is almost non existent. Nevertheless, the thought of mutating a Proline into a Glycine at position 22 intrigued me, so I spent a few minutes simulating it. Here is what I found out:

Method

The 3D-structure of my protein of interest was obtained from the UniProt database using Reprof. The structural information was obtained from the analysis of PDB: 3NIR. Annotations were obtained from UniProt entry CRAM_CRAAB.

Amino Acids

I was interested in the mutation of a Proline into a Glycine at position 22.

The figure below shows the schematic structures of the original (left) and the mutant (right) amino acid. The backbone, which is the same for each amino acid, is colored red. The side chain, unique for each amino acid, is colored black.

 mutates into 

Each amino acid has its own specific size, charge, and hydrophobicity-value. The original wild-type residue and newly introduced mutant residue differ in these properties: the mutant residue is smaller than the wild-type residue, while the wild-type residue is more hydrophobic than the mutant residue.

Variants

A mutation to “S” was found at this position, which differs from the mutation I was simulating. The effect of this variant is annotated as: In isoform SI.

Conservation

The wild-type residue is not conserved at this position. Another residue type was observed more often at this position in other homologous sequences. This means that other homologous proteins exist with that other residue type than with the wild-type residue in my protein sequence, but the other residue type is not similar to my mutant residue. Therefore, the mutation is possibly damaging.

Domains

This residue is part of an interpro domain named: Thionin IPR001010

The mutated residue is located on the surface of a domain with unknown function. The residue was not found to be in contact with other domains of which the function is known within the used structure. However, contact with other molecules or domains is still possible and might be affected by this mutation.

Amino Acid Properties

The wild-type and mutant amino acids differ in size. The mutant residue is smaller than the wild-type residue. This will cause a possible loss of external interactions.

The hydrophobicity of the wild-type and mutant residue differs. The mutation might cause loss of hydrophobic interactions with other molecules on the surface of the protein.

Images

Overview of the protein in ribbon-presentation. The protein is coloured by element; α-helix=blue, β-strand = red, turn=green, and random coil=cyan.

Overview of the protein in ribbon-presentation. The protein is coloured grey, the side chain of the mutated residue is coloured magenta and shown as small balls.

Close-up of the mutation. The protein is coloured grey, the side chains of both the wild-type and the mutant residue are shown and coloured green and red respectively.

Close-up of the mutation (seen from a slightly different angle). The protein is coloured grey, the side chains of both the wild-type and the mutant residue are shown and coloured green and red (not show from this angle) respectively.

Close-up of the mutation (seen from a slightly different angle). The protein is coloured grey, the side chains of both the wild-type and the mutant residue are shown and coloured green and red respectively.

Movies

Close-up of the mutation. Both the wild-type and mutant side chain are shown in green and red respectively. The rest of the protein is show in grey.

Close-up of the mutation, same colours as animation 1. The animation shows alternating the wild-type side chain and the mutant side chain.

Citation

Protein structure analysis of mutations causing inheritable diseases. DOI: 10.1186/1471-2105-11-548. PubMed: 21059217.

Visiting the London Design Museum

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Yesterday I visited the Design Museum (“The world’s leading museum devoted to contemporary design in every form from architecture and fashion to graphics, product and industrial design”) in its spectacular new location on High Street Kensington (London), with my son.

The #newdesignmuseum opened its doors in its new location only 5 days ago. The building and renovation are great, and in a nice location: on the edge of Holland Park, with the added bonus of being near the Kyoto Garden, Muji, and not far from the Serpentine Gallery.

I was expecting more from the shop(s) and I felt the exhibitions lacked a more daring curating, and more compelling communication. Although the loose “Designer, Maker, User” theme was not bad, they could have definitely dug more into the concept.

Additionally, it felt the collection was not comprehensive enough, with an overwhelming majority of consumer electronic devices, and not enough from other disciplines like fashion, architecture, or even manufacturing.

All in all, a nice evening in a nice museum, but plenty of room for improvement.

Valencia (Spain) VC flows

Adam Gilfix, Brian de Luna, and Luke Heine, with the help of Dealroom.co, have created a very interesting data visualization tool for Venture Capital (VC) flows.

I know for a fact and from experience that VC activity in places like Silicon Valley, NY, Boston, or London is big. But even when I go back home (Valencia – Spain) for the holidays, there are all kinds of “VC” events, news, meetings, spaces… which, given the conservative and provincial nature of the “Valencian Investors” I have met, surprises me.

So I decided to check out Valencia (Spain) VC flows. Unsurprisingly, those “flows” (both inbound and outbound) are quite recent, very very small, extremely limited in geographical reach, and conservative in industries. See for yourself:

View post on imgur.com

View post on imgur.com

View post on imgur.com

Several caveats, though:

  • The data may not cover ALL VC activity in the region
  • Some activity may be wrongly identified (for example, there is a transaction coming from “Valencia – Venezuela”, which could be a coincidence, or most likely a data collection error)

Invited to speak at GIANT Health event in London

Right after I returned from Germany, and before departing for Paraguay, I was invited to speak at the GIANT Health event (the “global innovation and new technology health event), health in The Coronet, London.

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The event run for 3 days, November 16-18, with 3 parallel tracks, and it included over 200 speakers. I spoke November 18, in the main auditorium.

There was an exhibition area, with several companies and organizations showing their innovations and technologies.

The venue was quite “grunge”, and it made you feel more like you were performing in a rock concert, rather than speaking at a healthcare event. All in all a massive, interesting, and fun event (except for the poor kamikaze organizers 😉 ).

My company has been named “Top Scaleup in the UK”

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For second consecutive year, my company has been named “Top Scaleup in the UK”. This means that we are growing fast, and also that I get invited to cool events. One of those events was a reception and a ‘Ten Years From Now’ series of keynotes at the Royal Institution of Great Britain, another one a mentoring session at London’s City Hall, and another one a series of talks at Google Campus. Some of the people I met at those events were:

  • Brian Forda, Crypto Currency Professor, MIT
  • Maria Contreras-Sweet, Director, USA Small Business Administration
  • Megan Smith, US Chief Technology Officer, White House Office of Science and Technology Policy
  • Obi Felten, Director, Google X

Microsoft Future Decoded 2016

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November 1 I attended Future Decoded, the annual event where Microsoft and Partners present their forward looking products and concepts.

Besides some cool “event attractions” (like the Back To The Future Delorean, seeing how data is not completely deleted even if you deep freeze a hard drive, the Bloodhound record-breaking car, or seeing the inside of a Rolls Royce plane turbine), the key for me was to be able to demonstrate my company’s software running on an amazing 84” Microsoft Surface Hub, and attending the invitation-only Microsoft Executive Party at the Sunborn Yacht Hotel.